Anti-MS4A4A antibodies and methods of use thereof

A method of detecting MS4A4A protein in an individual or in a tissue sample derived from an individual comprising contacting the individual or the tissue sample derived from an individual with an isolated antibody that binds to the MS4A4A protein, wherein the antibody comprises a heavy chain variable region and a light chain variable region, wherein the heavy chain variable region comprises:

• an HVR-H1 comprising the amino acid sequence of SEQ ID NO:
• 94;
• an HVR-H2 comprising the amino acid sequence of SEQ ID NO:
• 96;
• and an HVR-H3 comprising the amino acid sequence of SEQ ID NO:
• 102;
• and the light chain variable region comprises:
• an HVR-L1 comprising the amino acid sequence of SEQ ID NO:
• 104;
• an HVR-L2 comprising the amino acid sequence of SEQ ID NO:
• 105;
• and an HVR-L3 comprising the amino acid sequence of SEQ ID NO:
• 107.

A method of detecting MS4A4A protein in an individual or in a tissue sample derived from an individual comprising contacting the individual or the tissue sample derived from an individual with an isolated antibody that binds to the MS4A4A protein, wherein the antibody comprises a heavy chain variable region comprising an HVR-H1, HVR-H2, and HVR-H3 and a light chain variable region comprising an HVR-L1, HVR-L2, and HVR-L3, wherein the antibody comprises the HVR-H1, HVR-H2, HVR-H3, HVR-L1, HVR-L2, and HVR-L3 of SEQ ID NOs:

• 94, 98, 100, 103, 105, and 107, respectively;
• SEQ ID NOs:
• 94, 96, 101, 103, 106, and 107, respectively;
• SEQ ID NOs:
• 94, 99, 100, 104, 105, and 107, respectively;
• SEQ ID NOs:
• 116, 118, 124, 130, 139, and 144, respectively;
• SEQ ID NOs:
• 116, 118, 124, 132, 139, and 144, respectively;
• SEQ ID NOs:
• 116, 118, 124, 133, 139, and 144, respectively;
• SEQ ID NOs:
• 116, 118, 124, 136, 139, and 144, respectively;
• SEQ ID NOs:
• 116, 118, 124, 130, 139, and 145, respectively;
• SEQ ID NOs:
• 116, 118, 124, 138, 141, and 144, respectively;
• SEQ ID NOs:
• 116, 118, 124, 130, 141, and 144, respectively;
• SEQ ID NOs:
• 116, 118, 125, 130, 139, and 145, respectively;
• SEQ ID NOs:
• 116, 118, 127, 131, 139, and 144, respectively;
• SEQ ID NOs:
• 116, 118, 129, 131, 139, and 144, respectively;
• SEQ ID NOs:
• 116, 118, 129, 132, 139, and 144, respectively;
• SEQ ID NOs:
• 116, 118, 129, 133, 139, and 144, respectively;
• SEQ ID NOs:
• 116, 118, 129, 134, 139, and 144, respectively;
• SEQ ID NOs:
• 116, 118, 129, 135, 139, and 144, respectively;
• SEQ ID NOs:
• 116, 118, 129, 136, 139, and 144, respectively;
• SEQ ID NOs:
• 147, 149, 154, 156, 160, and 163, respectively;
• SEQ ID NOs:
• 146, 150, 154, 156, 160, and 163, respectively;
• SEQ ID NOs:
• 147, 149, 154, 157, 159, and 163, respectively;
• SEQ ID NOs:
• 147, 151, 154, 156, 160, and 163, respectively;
• SEQ ID NOs:
• 147, 151, 154, 158, 159, and 163, respectively;
• SEQ ID NOs:
• 146, 152, 154, 156, 161, and 163, respectively;
• SEQ ID NOs:
• 146, 153, 154, 158, 159, and 163, respectively;
• or SEQ ID NOs:
• 311, 312, 313, 317, 318, and 319, respectively.