Antibodies binding to alpha-synuclein for therapy and diagnosis

An alpha-synuclein binding molecule, which comprises:

• a) VH-CDR1 comprising the amino acid sequence of SEQ ID NO:
• 691;
• VH-CDR2 comprising the amino acid sequence of SEQ ID NO:
• 692;
• and
• VH-CDR3 comprising the amino acid sequence of SEQ ID NO:
• 693;
• VL-CDR1 comprising the amino acid sequence of SEQ ID NO:
• 695;
• VL-CDR2 comprising the amino acid sequence of SEQ ID NO:
• 696;
• and
• VL-CDR3 comprising the amino acid sequence of SEQ ID NO:
• 697;
• or
• b) VH-CDR1 comprising the amino acid sequence of SEQ ID NO:
• 721;
• VH-CDR2 comprising the amino acid sequence of SEQ ID NO:
• 722;
• and
• VH-CDR3 comprising the amino acid sequence of SEQ ID NO:
• 723;
• VL-CDR1 comprising the amino acid sequence of SEQ ID NO:
• 725;
• VL-CDR2 comprising the amino acid sequence of SEQ ID NO:
• 616;
• and
• VL-CDR3 comprising the amino acid sequence of SEQ ID NO:
• 637;
• or
• c) VH-CDR1 comprising the amino acid sequence of SEQ ID NO:
• 791;
• VH-CDR2 comprising the amino acid sequence of SEQ ID NO:
• 792;
• and
• VH-CDR3 comprising the amino acid sequence of SEQ ID NO:
• 793;
• VL-CDR1 comprising the amino acid sequence of SEQ ID NO:
• 795;
• VL-CDR2 comprising the amino acid sequence of SEQ ID NO:
• 616;
• and
• VL-CDR3 comprising the amino acid sequence of SEQ ID NO:
• 797;
• or
• d) VH-CDR1 comprising the amino acid sequence of SEQ ID NO:
• 841;
• VH-CDR2 comprising the amino acid sequence of SEQ ID NO:
• 842;
• and
• VH-CDR3 comprising the amino acid sequence of SEQ ID NO:
• 843;
• VL-CDR1 comprising the amino acid sequence of SEQ ID NO:
• 845;
• VL-CDR2 comprising the amino acid sequence of SEQ ID NO:
• 846;
• and
• VL-CDR3 comprising the amino acid sequence of SEQ ID NO:
• 847;
• or
• e) VH-CDR1 comprising the amino acid sequence of SEQ ID NO:
• 621;
• VH-CDR2 comprising the amino acid sequence of SEQ ID NO:
• 622;
• and
• VH-CDR3 comprising the amino acid sequence of SEQ ID NO:
• 623;
• VL-CDR1 comprising the amino acid sequence of SEQ ID NO:
• 625;
• VL-CDR2 comprising the amino acid sequence of SEQ ID NO:
• 626;
• and
• VL-CDR3 comprising the amino acid sequence of SEQ ID NO:
• 627.