Polymeric forms of H-NOX proteins
AssigneeOmniox, Inc.
InventorsGregory Kapp, Laura Serwer, Natacha Le Moan, Stephen P. L. Cary
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Abstract
The invention provides polymeric H-NOX proteins for the delivery of oxygen with longer circulation half-lives compared to monomeric H-NOX proteins. Polymeric H-NOX proteins extravasate into and preferentially accumulate in tumor tissue for sustained delivery of oxygen. The invention also provides the use of H-NOX proteins as radiosensitizers for the treatment of brain cancers.
Claims15
A recombinant nucleic acid encoding a trimeric H-NOX protein, wherein the nucleic acid comprises two or more nucleic acids encoding three H-NOX monomers, wherein each H-NOX monomer comprises a T. tengcongensis H-NOX domain and a trimerization domain, wherein the H-NOX domain in each H-NOX monomer comprises a L144F substitution;
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- wherein the trimerization domain in each H-NOX monomer is a foldon domain of bacteriophage T4 fibritin.
Dependencies are inferred from the claim text.