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US 12,753,217 B2Granted
IL-10 muteins
AssigneesUniversite De Lille, University of Dundee
InventorsClaire Gorby, Ignacio Moraga Gonzalez, Suman Mitra
Life of this patent
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Abstract
The present disclosure relates to modified forms, or muteins, of IL-10, as well as variants thereof, which display improved features as compared to wild-type IL-10. The present invention further relates to the use of such modified forms, or muteins, of IL-10, as well as variants thereof in methods, including therapeutic methods.
Claims16
An IL-10 mutein, wherein the IL-10 mutein comprises substitutions of 1 to 10 amino acids comprising at least one amino acid substitution at positions 18, 92 and 99, as compared to full-length wild-type IL-10 (SEQ ID NO:
- 1), and does not contain any additional substitutions, wherein numbering is with respect to the wild-type IL-10 sequence shown in SEQ ID NO:
- 1, but excluding the signal peptide sequence which constitutes the first 18 amino acid residues in SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.