Anti-viral compositions and methods of making and using
AssigneesUniversity of Louisville Research Foundation, Inc., The United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsJoshua Fuqua, Krystal Hamorsky, Barry R. O'Keefe, Tinoush Moulaei, Kenneth E. Palmer
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Abstract
Provided herein are GRFT variants and methods of using such GRFT variants. The GRFT variants described herein can be PEGylated, which significantly improves the pharmacokinetics and decreases the immunogenicity of the GFRT composition.
Claims21
A mutant griffithsin (GRFT) polypeptide comprising the amino acid sequence of SEQ ID NO:
- 1, wherein a lysine is substituted in at least one amino acid position selected from the group consisting of 1, 5, 24, 61, 64, 80, 81, and 122.
A mutant griffithsin (GRFT) polypeptide comprising the amino acid sequence selected from the group consisting of SEQ ID NOs:
- 3-11, wherein the native lysine at positions 7 and 100 of the GRFT polypeptide comprising the amino acid sequence of SEQ ID NO:
- 1 has been substituted with arginine and a lysine is respectively substituted in one amino acid position selected from the group consisting of 1, 5, 24, 61, 64, 78, 80, 81, and 122.
Dependencies are inferred from the claim text.