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US 12,753,209 B2Granted
Ultrasmall gas-filled protein nanostructures
AssigneeWilliam Marsh Rice University
InventorsJiaozhi Lu, Zongru Li, Qionghua Shen
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Abstract
In one aspect, the present disclosure describes ultrasmall gas vesicle compositions comprising modified gas vesicle shell proteins. Also disclosed herein are polynucleotide sequences which encode such compositions. Methods of treatment comprising administering such gas vesicle compositions are also provided.
Claims11
A gas vesicle composition comprising:
- (A) a modified shell protein, wherein the amino acid sequence of the modified shell protein comprises a first fragment and a second fragment, wherein:
- (i) the first fragment comprises SEQ ID NO:
- 1;
- and
- (ii) the second fragment comprises SEQ ID NO:
- 2;
- and
- (B) at least one gas vesicle assembly protein selected from the group consisting of Bacillus megaterium gvpR, Bacillus megaterium gvpN, Bacillus megaterium gvpF, Bacillus megaterium gvpG, Bacillus megaterium gvpL, Bacillus megaterium gvpS, Bacillus megaterium gvpK, Bacillus megaterium gvpJ, Bacillus megaterium gvpT, Bacillus megaterium gvpU, Anabaena flos-aquae gvpN, Anabaena flos-aquae gvpJ, Anabaena flos-aquae gvpK, Anabaena flos-aquae gvpF, Anabaena flos-aquae gvpG, Anabaena flos-aquae gvpV, and Anabaena flos-aquae gvpW.
5 more elements
A fusion protein comprising SEQ ID NO:
- 1 and SEQ ID NO:
- 2.
Dependencies are inferred from the claim text.