Azaheteroaryl compound, preparation method therefor, and application thereof
AssigneeShanghai Aolu Biomedical Technology Co., Ltd.
InventorsShichao Ma, Zhongguo Zhang, Song Zhang, Wenjia Yuan
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Abstract
The present invention provides an azaheteroaryl compound, a pharmaceutically acceptable salt thereof, and a solvate thereof. The present invention also provides a preparation method for such a compound, a composition containing such a compound, and a pharmaceutical use of such a compound in the preparation of a drug for treating a disease or disorder related to the mechanism of action of an EED protein and/or a PRC2 protein compound.
Claims19
A compound represented by formula (I), a pharmaceutically acceptable salt thereof, a stereoisomer thereof, a solvate thereof or an isotope-labeled compound thereof:
- wherein
- A is
- X is N or CR7;
- R1 is
- R2 is H, C1-4 alkyl, C3-6 cycloalkyl or an unsubstituted amino group or an amino group substituted by C1-4 alkyl;
- or, the group
- R7 is independently H, hydroxyl, —CN, halogen, C1-4 alkoxy or C1-4 alkyl.
A compound as follows:
- wherein R3 is independently ethyl, monofluoromethyl, difluoromethyl or trifluoromethyl.
Dependencies are inferred from the claim text.