Sirt6 activators

A compound according to Formula (I):

• or a pharmaceutically acceptable salt, tautomer, or isotopologue thereof,
• wherein:
• represents a single or double bond;
• X is NR5 or N or O or C;
• R5 is chosen from hydrogen, alkyl, cycloalkyl, alkoxyalkyl, alkylcarbonyl, or alkylsulfonyl;
• A is a five to ten membered ring chosen from heteroaryl, or fused heteroaryl;
• R1, R2, R4 are independently chosen from hydrogen, alkyl, cycloalkyl, haloalkyl, haloalkoxy, alkoxy, halo, cyano, carboxy, alkoxycarbonyl-R8, alkylcarbonyl-R8, aminocarbonyl, alkylaminocarbonyl-R8, alkoxyalkyl, aminoalkyl, aminoalkoxy, hydroxyl, and hydroxyalkyl;
• R3 is a four to eight membered heterocycle, substituted with one or more R6 substituents;
• R6 is chosen from hydrogen, hydroxyl, halo, alkyl-R7, alkoxy, cycloalkyl, carbonyl-R7, alkylcarbonyl-R7, alkylsulfonyl, heteroaryl, or heterocyclyl;
• wherein R7 is chosen from hydrogen, hydroxyl, halo, alkoxy, amino, cyano, alkylamino, dialkylamino, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, heterocyclyl, or heteroaryl;
• wherein R7 is chosen from hydrogen, halo, hydroxyl, cycloalkyl, alkoxy, or alklysulfonyl.