Aminopyrimidine compounds

A compound of the formula IA, IB, II, or IIA, or a pharmaceutically acceptable salt thereof:

• wherein
• R1 is H, F, Cl, Br, C1-6alkyl, CN, C1-6haloalkyl, —C(O)NH2, —C(O)NHC1-6alkyl, or —C(O)N(C1-6alkyl)2;
• R2 is a heteroaryl comprising 5-10 atoms optionally substituted with 1, 2, 3, or 4 independently selected R5;
• X is selected from —CH— and N;
• R3 is H, F, Cl, Br, OC1-6alkyl, C1-6alkyl, C3-6cycloalkyl, C1-6haloalkyl, OC1-6haloalkyl, NO2, NH2, —NHCO—(C1-C6-alkyl), C1-6alk-NHC(O)CR10═CHR10, NHC(O)CR10═CHR10, —NHCOCH═CHCH2N(Me)2, NHSO2CR10═CHR10, or O(C1-6alk) heterocycloalkyl;
• R3a is H, F, Cl, OC1-6alkyl, C1-6alkyl, C3-6cycloalkyl, C1-6haloalkyl, OC1-6haloalkyl, NO2, NH2, —NHCO—(C1-C6-alkyl), C1-6alk-NHC(O)CR10═CHR10, NHC(O)CR10═CHR10, —NHCOCH═CHCH2N(Me)2, NHSO2CR10═CHR10, or O(C1-6alk) heterocycloalkyl;
• R5 is F, Cl, Br, C1-6alkyl, C3-6cycloalkyl, OC1-6alkyl, C(O)C1-6alkyl, hydroxyC1-6alkyl, NH2, C1-6alk-NHC(O)CR10═CHR10, NHC(O)CR10═CHR10, NHC(O)CH═CH—C1-6alk-NH2, NHC(O)CH═CH—C1-6alk-NHC1-6alkyl, NHC(O)CH═CH—C1-6alk-N(C1-6alkyl)2, NHSO2CR10═CHR10, NHC(O)C1-6alkyl, or NHC(O)C3-6cycloalkyl;
• each R10 is independently H, F, Cl, C1-6alkyl, C1-6haloalkyl, C1-6alkoxy, or C1-6hydroxyalkyl;
• R4 is selected from the group consisting of:
• W is selected from the group consisting of —CH2—, C(O)—, —CH(OH)— and —N(R8)—;
• R8 is selected from the group consisting of —H, optionally substituted C1-C6-alkyl, optionally substituted C1-C6-alkenyl, and —C3-C6-cycloalkyl;
• each instance of R9 is independently selected from the group consisting of optionally substituted C1-C6-alkyl, optionally substituted C1-C6-alkenyl, and C3-C6-cycloalkyl;
• and each optionally substituted alkyl or optionally substituted alkenyl, when substituted, is substituted with one or more independently selected hydroxy, halogen, C1-C3-alkoxy, C1-C3-alkylthio, —CN, C3-C6-cycloalkyl, C1-C3-hydroxyalkyl, C2-C6 alkenyl, C2-C6-alkynyl, —CF3, —OCF3, NH2, NHC1-6alkyl, N(C1-6alkyl)2.