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US 12,753,156 B2Granted
Solid state form of tafamidis and a process for its preparation
OwnerGiuseppe Barreca, Luca Carcone +4inventors
InventorsGiuseppe Barreca, Luca Carcone, Piero Paravidino, Daniele Pengo, Massimo Zampieri, Liming Huang
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Abstract
A crystalline form of 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid and a method for its preparation are described. The crystalline form is further suitable as intermediate compound to prepare Form 1, Form 4 and Form M with improved stability and purity.
Claims14
A crystalline form of 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid, characterized by an XRPD profile comprising the peaks at 6.4, 9.6, 13.5, 16.3, 18.2, 20.4 and 27.5 degrees 2θ, when collected with the Kα radiation of copper (λ=1.5418 Å).
Dependencies are inferred from the claim text.