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US 12,753,155 B2Granted
Methods of coupling a carbon containing moiety to an amine containing moiety
AssigneePurdue Research Foundation
InventorsRobert Graham Cooks, Pallab Basuri, Nicolás M. Morato, Thalappil Pradeep
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Abstract
The invention generally relates to methods of coupling a carbon containing moiety to an amine containing moiety.
Claims18
A method of coupling a protonated carbon containing moiety to an ortho amine containing moiety to form a benzimidazole reaction product, the method comprising:
- generating a microdroplet comprising a protonated carbon containing moiety and an ortho amine containing moiety, wherein the microdroplet comprises an acidic surface that facilitates a reaction between the protonated carbon containing moiety and the ortho amine containing moiety and generates a benzimidazole reaction product comprising a carbon-nitrogen bond via the amine of the amine containing moiety, wherein the carbon containing moiety comprises a protonated carboxylic acid, with the proviso that the ortho amine containing moiety does not contain a strong electron withdrawing group.
A method of producing a benzimidazole, the method comprising:
- generating a microdroplet comprising a carboxylic acid and an aromatic-1,2-diamine, wherein the microdroplet comprises an acidic surface that facilitates a reaction between the carboxylic acid and the aromatic-1,2-diamine and generates a benzimidazole.
Dependencies are inferred from the claim text.