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US 12,753,147 B2Granted
Nanomaterials comprising acetals
AssigneeBeam Therapeutics Inc.
InventorsGregory Lawrence Hamilton, Neeraj Narendra Patwardhan, Cory Dane Sago, Mina Fawzy Shehata, Milloni Balwantkumar Chhabra
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Abstract
The present disclosure describes compositions, preparations, nanoparticles (such as lipid nanoparticles), and/or nanomaterials and methods of their use.
Claims12
A compound of Formula I′:
- or its N-oxide, or a pharmaceutically acceptable salt thereof, wherein
- L1 is C1-6 alkylenyl;
- each L2 is independently optionally substituted C2-15 alkylenyl;
- L3 is optionally substituted C1-10 alkylenyl;
- X is —OC(O)—, —C(O)O—, or —OC(O)O—;
- each R′ is independently selected from the group consisting of:
- R is hydrogen
- or an optionally substituted group selected from C6-20 aliphatic, 3- to 12-membered cycloaliphatic 1-adamantyl, 2-adamantyl, sterolyl, and phenyl;
- R1 is selected from the group consisting of
6 more elements
A compound selected from:
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.