Methods to enhance the safety of transcranial ultrasound stimulation procedures

A system comprising:

• a cranial volume imaging scan scanner configured to obtain a cranial volume image scan data of a subject;
• at least one ultrasound probe comprising a plurality of ultrasound elements configured to deliver neuromodulation to the subject;
• ultrasound probe drive electronics coupled to the ultrasound probe, the ultrasound probe drive electronics configured to adjust a phase of signals provided to the at least one ultrasound probe;
• a neuronavigation system configured to acquire probe orientation in a nasion-ear coordinate system;
• an electroencephalography (EEG) system with one or more EEG electrodes;
• and
• at least one processor executing an application that, when executed, causes the at least one processor to at least:
• estimate acoustic properties of a head of the subject based on the cranial volume image scan data;
• acquire a location of the at least one ultrasound probe based on data from the neuronavigation;
• transform the cranial volume imaging scan data into the nasion-ear coordinate system;
• generate a simulated acoustic field within the head in real-time based on the acoustic properties, the location of the at least one ultrasound probe, and a set of transmit voltage phases utilized for the at least one ultrasound probe to illustrate whether the location the of the probe requires correction;
• and
• display the simulated acoustic field in a user interface, wherein the simulated acoustic field is overlaid onto anatomical data associated with the cranial volume image scan data.