Systems and methods for planning of cardiac radiation therapy

A system for predicting a location of target heart region for cardiac ablation, the system comprising:

• one or more processors;
• and
• a memory to store computer code instructions, the computer code instructions when executed cause the one or more processors to:
• generate a three-dimensional (3D) model of a heart of a patient based on medical images of the patient;
• estimate, using the 3D model of the heart and electrophysiology data of the patient, one or more mechanical properties that drive motion of the heart of the patient;
• generate, using the 3D model and the one or more mechanical properties, a simulated motion pattern of the heart of the patient over a cardiac cycle;
• iteratively refine the simulated motion pattern within the 3D model based at least in part on a comparison between the simulated motion pattern and an estimated motion pattern derived from the medical images;
• identify a region of interest (ROI) of the heart of the patient to be radiated;
• determine, using the simulated motion pattern of the heart of the patient, a location of the ROI at a predefined time instance within the cardiac cycle;
• and
• output a treatment planning parameter configured for use by a cardiac radiotherapy planning system, the treatment planning parameter specifying at least one of beam geometry, beam intensity, dose distribution, or timing of beam delivery relative to the cardiac cycle, thereby causing the cardiac radiotherapy planning system to conduct a cardiac ablation treatment that targets the ROI while reducing radiation exposure to surrounding or an intervening tissue.

A non-transitory computer-readable medium including computer code instructions stored thereon, the computer code instructions when executed cause one or more processors to:

• generate a three-dimensional (3D) model of a heart of a patient based on medical images of the patient;
• estimate, using the 3D model of the heart and electrophysiology data of the patient, one or more mechanical properties that drive motion of the heart of the patient;
• generate, using the 3D model and the one or more mechanical properties, a simulated motion pattern of the heart of the patient over a cardiac cycle;
• iteratively refine the simulated motion pattern within the 3D model based at least in part on a comparison between the simulated motion pattern and an estimated motion pattern derived from the medical images;
• identify a region of interest (ROI) of the heart of the patient to be radiated;
• determine, using the simulated motion pattern of the heart of the patient, a location of the ROI at a predefined time instance within the cardiac cycle;
• and
• output a treatment planning parameter configured for use by a cardiac radiotherapy planning system, the treatment planning parameter specifying at least one of beam geometry, beam intensity, dose distribution, or timing of beam delivery relative to the cardiac cycle, thereby causing the cardiac radiotherapy planning system to conduct a cardiac ablation treatment that targets the ROI while reducing radiation exposure to surrounding or an intervening tissue.