Tissue stimulating devices, systems, and methods

An orthopedic prosthesis for stimulating bone growth comprising:

• a substrate comprising at least one bone-facing surface;
• a first piezoelectric nanostructure coupled to the at least one bone-facing surface at a first location;
• a second piezoelectric nanostructure coupled to the at least one bone-facing surface at a second location;
• and
• a conductor comprising a graphene nanosheet electrically coupled with the first piezoelectric nanostructure and the second piezoelectric nanostructure,
• wherein:
• the first piezoelectric nanostructure is configured to generate a first electric charge in response to a first mechanical force applied to the first piezoelectric nanostructure;
• the second piezoelectric nanostructure is configured to generate a second electric charge in response to a second mechanical force applied to the second piezoelectric nanostructure;
• and
• the conductor is configured to:
• transfer the first electric charge to the second piezoelectric nanostructure;
• and
• transfer the second electric charge to the first piezoelectric nanostructure to promote bone growth on at least one of the first location and the second location of the at least one bone-facing surface.

An orthopedic prosthesis for stimulating bone growth comprising:

• a substrate comprising:
• a first bone-facing surface;
• and
• a second bone-facing surface, opposite the first bone-facing surface;
• a first piezoelectric nanostructure coupled to the first bone-facing surface;
• a second piezoelectric nanostructure coupled to the second bone-facing surface;
• and
• at least one interconnect comprising a graphene nanosheet in electrical communication with at least one of the first piezoelectric nanostructure and the second piezoelectric nanostructure,
• wherein:
• the first piezoelectric nanostructure is configured to generate a first electric charge in response to a compression force applied to the first piezoelectric nanostructure;
• the second piezoelectric nanostructure is configured to generate a second electric charge in response to the compression force applied to the second piezoelectric nanostructure;
• and
• the at least one interconnect is configured to transmit at least one of the first electric charge and the second electric charge to promote bone growth on at least one of the first bone-facing surface and the second bone-facing surface.