Eluting perfusion catheters and related methods

A perfusion catheter assembly, comprising:

• a balloon including a series of helical windings, wherein, when in an inflated configuration, an outer surface of the balloon forms a valley between adjacent helical windings and an inner surface of the balloon defines a passage for bodily fluid to flow;
• a bioactive layer including one or more substances formulated to treat a tissue at or near a wall of a blood vessel;
• a base layer underlying the bioactive layer and lacking any drugs and therapeutic agents, the base layer configured to fill the valley between adjacent helical windings;
• and
• an elongate shaft operably attached to the balloon and including a lumen in fluid communication with the series of helical windings, wherein a distal end of the lumen is fluidly coupled with a distal end of the balloon such that the lumen is configured to allow a flow of fluid into the series of helical windings in a distal-to-proximal direction to move the balloon from a deflated configuration to the inflated configuration.

A perfusion catheter assembly, comprising:

• a balloon including a series of helical windings, wherein, when in an inflated configuration, an inner surface of the balloon defines a passage for bodily fluid to flow;
• a bioactive layer including one or more substances formulated to treat a tissue at or near a wall of a blood vessel;
• a base layer positioned between an outer surface of the balloon and the bioactive layer, the base layer lacking any drugs and therapeutic agents and configured to provide a smooth foundation over the series of helical windings of the balloon;
• a containment structure surrounding at least a portion of the bioactive layer, thereby shielding the bioactive layer from insertion shear forces or bodily liquid solvents;
• and
• an elongate shaft operably attached to the balloon and including a lumen in fluid communication with the series of helical windings, wherein a distal end of the lumen is fluidly coupled with a distal end of the balloon such that the lumen is configured to allow a flow of fluid into the series of helical windings in a distal-to-proximal direction to move the balloon from a deflated configuration to the inflated configuration.