Therapeutic wearable articles

A treatment delivery system for integration with a wearable article, the system including a pliable assembly of layers, comprising:

• a receptacle layer having a surface for containing a treatment agent and arranged to orient against the skin of an intended wearer or outside the wearable article, and wherein the treatment agent includes at least one of pharmaceuticals, nutraceuticals, homeopathic, herbal treatment agent;
• a coupled backing layer with a waterproof rating of at least 5,000 millimeters (mm) and a breathability score (RET) of 20 or less that allows less than 30% of the treatment agent to migrate through the backing layer;
• the delivery system being shaped and configured to correspond to and mimic a predetermined nervous system pathway of the intended wearer and to deliver the treatment agent to the intended wearer's skin along the pathway to provide a transdermal delivery and therapeutic effect;
• wherein the treatment delivery system includes a bonding section for bonding and integrating the treatment delivery system to a selected portion of the wearable article that maps to the predetermined nervous system pathway, and wherein the bonding section is disposed along at least one edge of the system and comprises an adhesive, chemical or thermal bonding material;
• and wherein the assembly of layers form a discrete element that is integratable with a base layer of the wearable article by the bonding section in a manner that the backing layer is disposed between the receptacle layer and the base layer.