Syringe assembly including pressurized sterile air

A syringe assembly comprising:

• a barrel defining a chamber therein, wherein the barrel includes a proximal portion and a distal portion;
• pressurized sterile fluid in the chamber;
• a plunger including a piston slidable in the chamber in a sealing relation to displace the pressurized sterile fluid in the chamber, wherein the pressurized sterile fluid is retained in the chamber when the plunger is stationary;
• a seal disposed in the distal portion of the barrel and configured to retain the pressurized sterile fluid in the chamber between the piston of the plunger and the seal when the plunger is stationary, wherein the seal forms an opening to permit ingress or egress of a fluid therethrough when the plunger is displaced in a proximal direction or a distal direction, respectively;
• and
• a needle assembly extending distally from the barrel and in fluid communication with the chamber of the barrel, wherein the seal is adjacent the needle assembly.