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US 12,752,023 B2Granted
Near-infrared dyes and conjugates for targeting tumors
AssigneeLahjavida, LLC
InventorsLyle D. Small, Ruizheng Wang
Life of this patent
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Abstract
A conjugate including a tumor-targeting NIR dye coupled to a therapeutic agent via a linker, whereby the dye functions to direct the conjugate and correspondingly, the therapeutic agent, to a target tumor cell population. Additionally, a method of killing tumor cells by directing a conjugate including a tumor-targeting NIR dye coupled to a therapeutic agent via a linker to a target tumor cell population.
Claims2
A method of killing tumor cells, comprising:
- administering a conjugate to a subject, said conjugate comprising:
- a tumor-targeting near-infrared dye;
- and
- a therapeutic agent coupled to said dye via a linker comprising a cleavable portion comprising protease sensitivity;
- wherein said dye targets said therapeutic agent to tumor cells;
- and
- wherein said conjugate comprises one of:
4 more elements
A method of killing tumor cells, comprising:
- administering a conjugate to a subject, said conjugate comprising:
- a tumor-targeting near-infrared dye;
- and
- a therapeutic agent coupled to said dye via a linker comprising a cleavable portion comprising protease sensitivity:
- wherein said dye targets said therapeutic agent to tumor cells;
- and
- wherein said conjugate is selected from the group consisting of:
4 more elements
Dependencies are inferred from the claim text.