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US 12,752,008 B2Granted
Composition containing buffer
AssigneePerseus Proteomics Inc.
InventorsYuichi Funase, Masahiro Kurokawa
Life of this patent
Estimating the term…
Abstract
Provided is a composition containing a buffer to be used at the time of labeling of a chelated targeting agent with 90Y, 153Sm, 165Dy, 165Er, 166Ho, or 177Lu. At least one kind of buffer selected from the group consisting of benzoic acid, maleic acid, fumaric acid, succinic acid, and salts thereof is incorporated in a composition containing a chelated targeting agent.
Claims12
A kit, comprising:
- (a) a chelated targeting agent comprising a conjugate of a chelate group having a DOTA structure and an anti-CDH3 antibody targeting moiety;
- (b) at least one buffer selected from the group consisting of benzoic acid, maleic acid, and salts thereof;
- and
- (c) an instruction describing preparing a radioactive metal-labeled chelated targeting agent by mixing a mixture of the chelated targeting agent and the buffer with a radioactive metal selected from the group consisting of 90Y and 177Lu.
1 more element
A kit, comprising:
- (a) a chelated targeting agent comprising a conjugate of a chelate group comprising a DOTA structure and an anti-CDH3 antibody targeting moiety;
- (b) at least one compound selected from the group consisting of benzoic acid, maleic acid, a conjugate base of benzoic acid, a conjugate base of maleic acid, a mixture of benzoic acid and a conjugate base of benzoic acid and a mixture of maleic acid and a conjugate base of maleic acid;
- and
- (c) an instruction describing preparing a radioactive metal-labeled chelated targeting agent by mixing a mixture of the chelated targeting agent and the compound with a radioactive metal selected from the group consisting of 90Y and 177Lu.
1 more element
A kit, comprising:
- (a) a chelated targeting agent comprising a conjugate of a chelate group having a DOTA structure and an anti-CDH3 antibody targeting moiety;
- (b) at least one buffer selected from the group consisting of benzoic acid, maleic acid, and salts thereof;
- and
- (c) a radioactive metal selected from the group consisting of 90Y and 177Lu,
- wherein the radioactive metal is in a separate vessel from a vessel containing the chelated targeting agent and the buffer.
2 more elements
A kit, comprising:
- (a) a chelated targeting agent comprising a conjugate of a chelate group comprising a DOTA structure and an anti-CDH3 antibody targeting moiety;
- (b) at least one compound selected from the group consisting of benzoic acid, maleic acid, a conjugate base of benzoic acid, a conjugate base of maleic acid, a mixture of benzoic acid and a conjugate base of benzoic acid and a mixture of maleic acid and a conjugate base of maleic acid;
- and
- (c) a radioactive metal selected from the group consisting of 90Y and 177Lu,
- wherein the radioactive metal is in a separate vessel from a vessel containing the chelated targeting agent and the compound.
2 more elements
Dependencies are inferred from the claim text.