Enhancement of immune response with oral immunoglobulin polypeptides

A method of enhancing the immune response of a subject, improving the response of a subject to vaccination, stimulating the cellular immune system of a subject, modulating the cellular immune system of a subject or enhancing resistance of a subject to infection, improving response to vaccination, stimulating the cellular immune system, modulating the cellular immune system, enhancing resistance to infection, improving well-being of a subject suffering from an immune imbalance, improving well-being of a subject suffering from an immunopathology, or improving the well-being of a subject suffering from allergy, comprising:

• orally administering to said subject an effective amount of a protein product comprising an immunoglobulin polypeptide fraction derived from a milk product of a domestic animal,
• wherein said immunoglobulin polypeptide fraction comprises a frequency of representation of at least 60% of the T-cell exposed motifs found in a reference database of T-cell exposed motifs selected from the group consisting of T-cell exposed motifs found in human germline immunoglobulin variable region sequences, T-cell exposed motifs found in somatically mutated human immunoglobulin variable region sequences and T-cell exposed motifs found in immunoglobulin constant chains,
• wherein said reference database comprises at least 40,000 unique T-cell exposed motifs, and
• wherein said immunoglobulin polypeptide fraction further comprises greater than about 25% w/w immunoglobulin polypeptides,
• wherein w/w is the weight of the immunoglobulin polypeptides per the total weight of the fraction on a dry basis.