Lipidated FLIPr and uses thereof in vaccine
AssigneeNational Health Research Institutes
InventorsHsin-Wei Chen, Ming-Shu Hsieh, Shih-Jen Liu, Ching-Len Liao
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Abstract
The present disclosure relates to a vaccine composition, comprising a recombinant lipidated FLIPr (rLF), and the use thereof in enhancing humoral and cellular immune responses. The recombinant lipidated FLIPr of present invention may be used as a vaccine candidate that can induce anti-FLIPr responses to overcome FLIPr-mediated inhibition. And unexpectedly, the recombinant lipidated FLIPr may be used as an adjuvant that can enhance other vaccine immune responses, especially in subunit vaccines and inactivated virus vaccines.
Claims11
A vaccine composition, comprising a recombinant lipidated FLIPr (rLF) and an immunogen, wherein the recombinant lipidated FLIPr (rLF) and the immunogen are present as separate molecular entities, and wherein the recombinant lipidated FLIPr (rLF) is used to enhance a vaccine immune response of the immunogen.
Dependencies are inferred from the claim text.