Mutant influenza B/Victoria lineage virus hemagglutinin proteins
AssigneeModernaTX, Inc.
InventorsRaffael Nachbagauer, Farbod Mahmoudinobar, Elif Nihal Korkmaz
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Abstract
Some aspects of the disclosure relate to vaccines (e.g., RNA vaccines (e.g., mRNA vaccines)) for seasonal influenza viruses as well as methods of using the vaccines. Also described are combination vaccines (e.g., RNA vaccines (e.g., mRNA vaccines)) for seasonal influenza viruses and other respiratory viruses (e.g., respiratory syncytial viruses and coronaviruses), as well as methods of using the vaccines.
Claims9
A mutant influenza B/Victoria lineage virus hemagglutinin (HA) protein having an amino acid sequence comprising an amino acid substitution relative to a reference influenza B/Victoria lineage virus HA protein amino acid sequence, wherein the amino acid sequence of the mutant influenza B/Victoria lineage virus HA protein comprises one or more of (a)-(s):
- (a) a tyrosine at position 381 and a valine at position 288;
- (b) a cysteine at position 27 and a cysteine at position 349;
- (c) a cysteine at position 295 and a cysteine at position 328;
- (d) a cysteine at position 399 and a cysteine at position 473;
- (e) a cysteine at position 422 and a cysteine at position 444;
- (f) a cysteine at position 118 and a cysteine at position 216;
- (g) a cysteine at position 237 and a cysteine at position 261;
- (h) a cysteine at position 363 and a cysteine at position 480;
- (i) a cysteine at position 364 and a cysteine at position 483;
- (j) a cysteine at position 365 and a cysteine at position 476;
- (k) a cysteine at position 366 and a cysteine at position 479;
- (l) a cysteine at position 367 and a cysteine at position 483;
- (m) a cysteine at position 435 and a cysteine at position 428;
- (n) a cysteine at position 494 and a cysteine at position 483;
- (o) a cysteine at position 494 and a cysteine at position 480;
- (p) a proline at position 416, a proline at position 417, a proline at position 434, and a proline at position 433;
- (q) a proline at position 434 and a proline at position 433;
- (r) a proline at position 515, and a proline at position 516;
- (s) a phenylalanine at position 473;
- wherein the positions of (a)-(s) are numbered by alignment to SEQ ID NO:
- 71.
Dependencies are inferred from the claim text.