Methods of reducing neuroinflammation

A method of treating Parkinson's Disease in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a multi-chain chimeric polypeptide comprising:

• (a) a first chimeric polypeptide comprising:
• (i) a first target-binding domain comprising a sequence that is at least 90% identical to SEQ ID NO:
• 4;
• (ii) a soluble tissue factor domain comprising a sequence that is at least 90% identical to SEQ ID NO:
• 1;
• and
• (iii) a first domain of a pair of affinity domains comprising a sequence that is at least 90% identical to SEQ ID NO:
• 18;
• (b) a second chimeric polypeptide comprising:
• (i) a second domain of a pair of affinity domains comprising a sequence that is at least 90% identical to SEQ ID NO:
• 16;
• and
• (ii) a second target-binding domain comprising a sequence that is at least 90% identical to SEQ ID NO:
• 4,
• wherein:
• the first chimeric polypeptide and the second chimeric polypeptide associate through the binding of the first domain and the second domain of the pair of affinity domains;
• and
• the first target-binding domain and the second target-binding domain each bind specifically to a ligand of TGF-β receptor II (TGF-βRII).