Induced pluripotent stem cell derived glial enriched progenitor cells for the treatment of white matter stroke
AssigneeThe Regents of the University of California
InventorsStanley Thomas Carmichael, Irene Lorenzo Llorente, William E. Lowry
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Abstract
In various embodiments methods and compositions for improving a recovery of a subject after a cerebral ischemic injury, such as white matter stroke are provided. In certain embodiments, the methods involve administering human induced pluripotent glial enriched progenitor cells into the brain of the subject.
Claims13
A method of improving recovery of a human after a cerebral ischemic injury, said method comprising cerebrally administering a therapeutically effective amount of differentiated cells to said human, wherein the differentiated cells are derived from human induced pluripotent stem cells (hiPSCs) or human embryonic stem cells (hESCs) that have been differentiated and cultured in NPC medium containing DFX for 3-5 days to produce cells whose differentiation potential is restricted to astrocytes;
- wherein the differentiated cells are syngeneic, allogenic, or are derived from the human;
- and wherein said differentiated cells are directly injected into or at about 0.05 mm to about 3 mm from the infarct core in the brain of said human during the subacute time period after a white matter stroke.
A method of slowing myelin loss, and/or promoting myelin repair, and/or promoting remyelination in a human having a demyelinating pathology that effects the central nervous system, said method comprising cerebrally administering a therapeutically effective amount of differentiated cells to said human, wherein the differentiated cells are derived from human induced pluripotent stem cells (hiPSCs) or human embryonic stem cells (hESCs) that have been differentiated and cultured in NPC medium containing DFX for 3-5 days to produce cells whose differentiation potential is restricted to astrocytes;
- wherein the differentiated cells are syngeneic, allogenic, or are derived from the human;
- and wherein said differentiated cells are directly injected into the brain of said human.
Dependencies are inferred from the claim text.