Antioxidant and antiviral compositions and methods
AssigneeMayo Foundation for Medical Education and Research
InventorsTimothy Peterson, Atta Behfar, Christopher Paradise
Life of this patent
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Abstract
Preparations of exosomes and/or Purified Exosome Product (PEP) include antioxidant proteins and antiviral proteins. Compositions that include exosomes and/or PEP can be used to treat subject having, or at risk of having, a condition or tissue damage caused, at least in part, by oxidative stress. Also, compositions that include exosomes and/or PEP can be used to treat subject having, or at risk of having, a viral infection.
Claims5
A method of treating tissue damage caused by oxidative stress in a subject having, or at risk of having, tissue damage caused by oxidative stress, the method comprising:
- administering to the subject a composition that includes exosomes comprising at least one antioxidant protein in an amount effective to reduce the likelihood or severity of tissue damage compared to a subject to whom the composition is not administered, the exosomes prepared by a process that comprises:
- freezing material comprising cells comprising the exosomes under conditions effective to disrupt the cells but maintain the structure of the exosomes;
- and
- thawing the frozen material at a controlled rate of from 0.1° C. to 5° C. per minute.
Dependencies are inferred from the claim text.