Small molecule inhibitors of viral replication
AssigneeThe Trustees of Princeton University
InventorsAlexander Ploss, Ila Nimgaonkar, Hahn Kim
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Abstract
Provided herein are methods involving a compound of the following structural formula: (I) or a pharmaceutically acceptable salt thereof, wherein values for the variables are as described herein. For example, methods for inhibiting replication of a virus, treating a viral infection, inhibiting heat shock protein 90 and treating a heat shock protein 90-mediated disease or condition using a compound of Structural Formula I are provided.
Claims16
A method of inhibiting replication of a virus, comprising contacting a cell infected with the virus with a compound represented by the following structural formula:
- or a pharmaceutically acceptable salt thereof, wherein:
- Ring A is aryl or heteroaryl, and is optionally substituted with one or more substituents independently selected from halo, hydroxy, alkyl, haloalkyl, alkoxy, haloalkoxy, —(CH2)0-2-aryl, —(CH2)0-2-heteroaryl, —(CH2)0-2-cycloalkyl, or —(CH2)0-2-heterocyclyl, carboxy or —O(CH2)mO—;
- m is 1, 2, 3, 4 or 5;
- L is —C(O)(CH2)p—, —C(O)(CH2)p—O— or heteroarylene, wherein p is 0, 1 or 2, and R is hydrogen, halo, hydroxy, alkyl, haloalkyl, alkoxy, haloalkoxy, alkenoxy, alkynoxy, —(CH2)0-2-aryl, or —(CH2)0-2-heteroaryl, and wherein heteroarylene is monocylic and does not form a fused ring with an adjacent ring in the compound;
- R1 is halo, hydroxy, alkyl, haloalkyl, alkoxy, haloalkoxy, alkenoxy, alkynoxy, —(CH2)0-2-aryl, or —(CH2)0-2-heteroaryl;
- and
- n is 0, 1, 2 or 3,
- wherein the aryl and heteroaryl of R and R1, and the heteroarylene of L are each optionally and independently substituted with one or more substituents selected from halo, alkyl, haloalkyl, amino, alkylamino, dialkylamino or carboxamido.
Dependencies are inferred from the claim text.