Quinazoline derivative, or preparation method therefor and use thereof

A compound represented by general formula (I) or a stereoisomer, a tautomer or a pharmaceutically acceptable salt thereof:

• wherein:
• Ra is cyano, —C(O)R3 or C1-C6 alkoxy;
• R1 are the same or different, and are each independently halogen, hydroxyl, amino, C1-C6 alkyl or C1-C6 alkoxy;
• wherein, the alkyl or alkoxy is optionally further substituted by one or more substituents selected from halogen, hydroxyl, cyano, amino, C1-C6 alkyl and C1-C6 alkoxy;
• R2 is C3-C6 cycloalkyl, 3-6 membered monocyclic heterocyclyl, 6-11 membered spiroheterocyclyl, 6-11 membered bridged heterocyclyl, 6-11 membered fused heterocyclyl or 6-11 membered fused ring;
• wherein, the cycloalkyl, monocyclic heterocyclyl, spiroheterocyclyl, bridged heterocyclyl, fused heterocyclyl or fused ring is optionally further substituted by one or more RAs;
• RA is each independently halogen, cyano, hydroxyl, amino, oxo, C1-C6 alkyl, C1-C6 alkoxy, C3-C6 cycloalkyl, 3-8 membered heterocyclyl, —C(O)R3 or —SO2R4, wherein, the alkyl, alkoxy or cycloalkyl is optionally further substituted by one or more substituents selected from halogen, nitro, cyano, hydroxyl, amino, C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkoxy and —SO2R4;
• the heterocyclyl is optionally further substituted by one or more substituents selected from halogen, nitro, cyano, hydroxyl, amino, oxo, C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkoxy, —C(O)R3 and —SO2R4;
• R3 is each independently C1-C6 alkyl, C1-C3 alkoxy, C3-C6 cycloalkyl, —NR5R6 or 3-6 membered heterocyclyl, wherein, the alkyl or cycloalkyl is optionally further substituted by one or more substituents selected from hydroxyl, halogen, nitro, amino, cyano, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkyl and C1-C6 haloalkoxy;
• the heterocyclyl is optionally further substituted by one or more substituents selected from hydroxyl, halogen, nitro, amino, cyano, oxo, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkyl and C1-C6 haloalkoxy;
• R4 is each independently amino, C1-C6 alkyl or C3-C6 cycloalkyl;
• R5 and R6 are each independently a hydrogen atom or C1-C6 alkyl, wherein, the alkyl is optionally further substituted by one or more substituents selected from hydroxyl, halogen, amino, cyano and C1-C6 alkoxy;
• or, R5 and Re together with the N atom bound therewith form a 4-10 membered heterocyclic ring, the formed heterocyclic ring is optionally further substituted with a substituent selected from halogen, cyano, hydroxyl, amino, oxo, C1-C6 alkyl, C1-C6 alkoxy, —C(O)R7 and C3-C6 cycloalkyl;
• R7 is C1-C3 alkyl or C3-C6 cycloalkyl, the alkyl or cycloalkyl is optionally further substituted by one or more substituents selected from hydroxyl, halogen, amino, cyano and C1-C6 alkoxy;
• and
• m is 0, 1, 2, 3 or 4.