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US 12,751,946 B2Granted
Topical anaesthetic composition having improved vasoconstrictor stability
AssigneeAnimal Ethics Pty Ltd
InventorLaurie Batt
Life of this patent
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Abstract
This invention relates to a topical anaesthetic composition having improved adrenaline stability, its method of manufacture, and its use as a topical anaesthetic, particularly in medical applications such as animal husbandry procedures.
Claims18
A topical anaesthetic composition comprising in percentage weight/weight (% w/w):
- 5% w/w ±10% variance of lignocaine salt;
- 4-0.5% w/w ±10% variance of bupivacaine salt;
- 0.5% w/w ±10% variance of cetrimide;
- 0.0045% w/w ±10% variance of adrenaline salt or ester;
- 10% w/w ±10% variance of liquid sorbitol (70%);
- 0.5% w/w ±10% variance of 2-hydroxyethyl cellulose;
- 0.0045% w/w ±10% variance of sodium metabisulfite;
- 0.250% w/w ±10% variance of citric acid;
- and
- 0.05% w/w ±10% variance of EDTA salt,
- wherein said composition has a final pH of approximately 2.4 to 3.4±10% variance, and the composition has a density in the range of 1.01 to 1.05 g/mL ±10% variance.
8 more elements
A composition comprising in percentage weight/volume (% w/v):
- about 5% w/v lignocaine hydrochloride;
- about 0.5% w/v bupivacaine hydrochloride;
- about 0.5% w/v cetrimide;
- about 0.0045% w/v adrenaline bitartrate;
- about 0.5% w/v to about 0.6% w/v 2-hydroxyethyl cellulose;
- about 0.0045% w/v sodium metabisulfite;
- about 10% w/v liquid sorbitol (70%);
- about 0.005% w/v colourant, such as a pigment or dye;
- about 0.25% w/v citric acid (anhydrous);
- about 0.05% w/v disodium EDTA;
- optionally, a pH adjuster, with a quantity to suit;
- and
- water, with a quantity to suit,
- wherein said composition has a final pH of about 2.9.
11 more elements
Dependencies are inferred from the claim text.