Compound for the treatment and prevention of central nervous system disorders
AssigneeAbaxys Therapeutics
InventorFrancisco Javier Garcia-Ladona
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Abstract
A pharmaceutical composition for use in the treatment and/or prevention of a central nervous system disorder, such as a motor disorder, a mood disorder, a neurological disorder, a neurodegenerative disorder, or an inflammatory disorder induced by a pathogenic factor or agent. The pharmaceutical composition includes a compound of formula (I): or any salt, derivative, isotope or mixture thereof, and at least one pharmaceutically acceptable excipient.
Claims10
A method of treating a central nervous system disorder in a subject in need thereof comprising a step of administration of a therapeutically effective amount of a pharmaceutical composition to said subject;
- wherein the pharmaceutical composition comprises a compound of formula (II)
- or a pharmaceutically acceptable salt and/or solvate thereof,
- wherein:
- R1, R2 and R11 are each independently C1-C3 alkyl,
- R3, R4, R5, R6, R7, R8, R9 and R10 are each independently selected from hydrogen, halogen, hydroxyl, —NH3, —NO3, —SH, C1-C3 alkyl, C1-C3 haloalkyl, C1-C3 alkoxy, and C1-C3 thioalkyl,
- R12, R13, R15 and R16 are each independently selected from hydrogen, halogen, hydroxyl, —NH3, —NO3, —SH, C1-C3 alkyl, C1-C3 haloalkyl, C1-C3 alkoxy, and C1-C3 thioalkyl, and
- R14 is C1-C3 alkyl,
- and at least one pharmaceutically acceptable excipient;
- wherein the central nervous system disorder comprises a neurological disorder selected from the group consisting of Epilepsy, Alzheimer's Disease (AD), Mild Cognitive Impairment (MCI), Attention-Deficit Hyperactivity Disorder (ADHD), Hyper-kinetic Disorder, agnosia, Amyotrophic Lateral Sclerosis (ALS), Huntington's disease, Lewy body disease, Parkinson's disease, Spinal muscular atrophy, ataxia, Canavan disease, dementia, neuralgia, migraine, headaches, and tension headaches.
Dependencies are inferred from the claim text.