Methods of treating influenza and poxvirus viral infections
AssigneeVeru Inc.
InventorsMitchell S. Steiner, Kester Gary Barnette
Life of this patent
Estimating the term…
Abstract
The present invention relates to methods of treating specific viral infections, such as an Orthomyxoviridae infection, in a subject in need thereof by administering to the subject a formulation having a therapeutically effective amount of a compound of Formula (I):
Claims18
A method of treating an Orthomyxoviridae infection in a subject in need thereof by administering to the subject a formulation having a therapeutically effective amount of a compound of Formula (I):
- wherein
- A is phenyl or indolyl, optionally substituted with at least one of (C1-C4)alkyl, halo(C1-C4)alkyl, O—(C1-C4)alkyl, O-halo(C1-C4)alkyl, (C1-C4)alkylamino, amino(C1-C4)alkyl, F, Cl, Br, I, CN, —CH2CN, NH2, hydroxyl, OC(O)CF3, —OCH2Ph, —NHCO—(C1-C4)alkyl, COOH, —C(O)Ph, C(O)O—(C1-C4)alkyl, C(O)H, —C(O)NH2 or NO2;
- B is an imidazole optionally substituted with at least one of (C1-C4)alkyl, halo(C1-C4)alkyl, O—(C1-C4)alkyl, O-halo(C1-C4)alkyl, F, Cl, Br, I, CN, —CH2CN, hydroxyl, or NO2;
- R1, R2 and R3 are independently at least one of hydrogen, (C1-C4)alkyl, halo(C1-C4)alkyl, O—(C1-C4)alkyl, O-halo(C1-C4)alkyl, (C1-C4)alkylamino, amino(C1-C4)alkyl, F, Cl, Br, I, CN, —CH2CN, NH2, hydroxyl, OC(O)CF3, —OCH2Ph, —NHCO—(C1-C4)alkyl, COOH, —C(O)Ph, C(O)O—(C1-C4)alkyl, C(O)H, —C(O)NH2 or NO2;
- X is a bond;
- Y is —C═O;
- and
- m is 1-3, or a pharmaceutically acceptable salt, hydrate, polymorph, or isomer thereof.
A method of treating an Orthomyxoviridae infection in a subject in need thereof by administering to the subject a formulation having a therapeutically effective amount of a compound of the Formula VII:
- wherein
- X is a bond;
- Q is S or NH;
- and
- A is a indolyl ring optionally substituted with at least one of (C1-C4)alkyl, halo(C1-C4)alkyl, O—(C1-C4)alkyl, O-halo(C1-C4)alkyl, (C1-C4)alkylamino, amino(C1-C4)alkyl, F, Cl, Br, I, CN, —CH2CN, NH2, hydroxyl, OC(O)CF3, —OCH2Ph, —NHCO—(C1-C4)alkyl, COOH, —C(O)Ph, C(O)O—(C1-C4)alkyl, C(O)H, —C(O)NH2 or NO2;
- or a pharmaceutically acceptable salt, hydrate, polymorph, or isomer thereof.
A method of treating an Orthomyxoviridae infection in a subject in need thereof by administering to the subject a formulation having a therapeutically effective amount of a compound of the Formula VII(c):
- wherein
- R4 and R5 are independently hydrogen, (C1-C4)alkyl, halo(C1-C4)alkyl, O—(C1-C4)alkyl, O-halo(C1-C4)alkyl, (C1-C4)alkylamino, amino(C1-C4)alkyl, F, Cl, Br, I, CN, —CH2CN, NH2, hydroxyl, OC(O)CF3, —OCH2Ph, —NHCO—(C1-C4)alkyl, COOH, —C(O)Ph, C(O)O—(C1-C4)alkyl, C(O)H, —C(O)NH2 or NO2;
- and
- n is 1-4;
- or a pharmaceutically acceptable salt, hydrate, polymorph, or isomer thereof.
A method of treating an Orthomyxoviridae infection in a subject in need thereof by administering to the subject a formulation having a therapeutically effective amount of a compound 17ya represented:
Dependencies are inferred from the claim text.