Methods for delivery of psychedelic medications by inhalation and systems for performing the methods

A method of treating a central nervous system (CNS) disorder or psychological disorder in a patient, comprising:

• administering to the patient, via inhalation, an aerosol comprising a psychedelic drug in a carrier, wherein the psychedelic drug is a compound of Formula (II) or a stereoisomer, pharmaceutically acceptable salt, solvate, or prodrug thereof
• wherein:
• X1 and X2 are deuterium,
• Y1 and Y2 are independently selected from hydrogen and deuterium,
• R is
• R2 is selected from hydrogen, deuterium, unsubstituted or substituted alkyl, unsubstituted or substituted allyl, unsubstituted or substituted alkenyl, unsubstituted or substituted alkynyl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted heterocycloalkyl, unsubstituted or substituted aryl, and unsubstituted or substituted heteroaryl,
• R4 is selected from hydrogen, deuterium, unsubstituted or substituted alkoxy, and unsubstituted or substituted phosphoryloxy,
• R5 is selected from hydrogen, deuterium, hydroxyl, and unsubstituted or substituted phosphoryloxy,
• R6 and R7 are selected from hydrogen, deuterium, and halogen, and
• R9, R10, and R11 are independently selected from hydrogen, unsubstituted or substituted alkyl, unsubstituted or substituted allyl, unsubstituted or substituted alkenyl, unsubstituted or substituted alkynyl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted heterocycloalkyl, unsubstituted or substituted aryl, and unsubstituted or substituted heteroaryl;
• wherein the CNS disorder or psychological disorder is at least one selected from the group consisting of melancholic depression, atypical depression, dysthymia, anxiety disorder, obsessive compulsive disorder, addiction disorder, opioid use disorder, amphetamine use disorder, nicotine use disorder, cocaine use disorder, post-traumatic stress disorder (PTSD), major depressive disorder (MDD), treatment-resistant depression (TRD), suicidal ideation and suicide attempts, bipolar I disorder, bipolar II disorder, cyclothymic disorder, obsessive-compulsive disorder (OCD), generalized anxiety disorder (GAD), social anxiety disorder, Alzheimer's disease, cluster headache, migraine headaches, attention deficit hyperactivity disorder (ADHD), pain and neuropathic pain, aphantasia, childhood-onset fluency disorder, major neurocognitive disorder, mild neurocognitive disorder, sexual dysfunction, gambling disorder, eating disorder, anorexia nervosa, bulimia nervosa, binge-eating disorder, paraphilic disorders, pedophilic disorder, exhibitionistic disorder, voyeuristic disorder, fetishistic disorder, sexual masochism disorder, sexual sadism disorder, and transvestic disorder.

A method of delivering a psychedelic drug to a patient in need thereof, comprising:

• administering a dry powder to the patient by inhalation via a dry powder inhaler, wherein the dry powder comprises the psychedelic drug, and the psychedelic drug is a compound of Formula (II) or a stereoisomer, pharmaceutically acceptable salt, solvate, or prodrug thereof
• wherein:
• X1 and X2 are deuterium,
• Y1 and Y2 are independently selected from hydrogen and deuterium,
• R is
• R2 is selected from hydrogen, deuterium, unsubstituted or substituted alkyl, unsubstituted or substituted allyl, unsubstituted or substituted alkenyl, unsubstituted or substituted alkynyl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted heterocycloalkyl, unsubstituted or substituted aryl, and unsubstituted or substituted heteroaryl,
• R4 is selected from hydrogen, deuterium, unsubstituted or substituted alkoxy, and unsubstituted or substituted phosphoryloxy,
• R5 is selected from hydrogen, deuterium, hydroxyl, and unsubstituted or substituted phosphoryloxy,
• R6 and R7 are selected from hydrogen, deuterium, and halogen, and
• R9, R10, and R11 are independently selected from hydrogen, unsubstituted or substituted alkyl, unsubstituted or substituted allyl, unsubstituted or substituted alkenyl, unsubstituted or substituted alkynyl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted heterocycloalkyl, unsubstituted or substituted aryl, and unsubstituted or substituted heteroaryl.