Topical ocular delivery of cromakalim
AssigneesQlaris Bio, Inc., Mayo Foundtation for Medical Education and Research
InventorsThurein M. Htoo, Michael P. Fautsch, Gary Allred, Ralph Casale, Barbara M. Wirostko
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Abstract
Aqueous ocular topical pharmaceutical formulations are provided that deliver an effective amount of (lev)cromakalim or a pharmaceutically acceptable salt thereof to treat an anterior or a posterior ocular disorder that responds to (lev)cromakalim, including glaucoma.
Claims29
A method of treating an ocular-related neurodegenerative disease affecting the posterior segment of the eye comprising administering an effective amount of an aqueous clear ocular topical pharmaceutical solution to a human in need thereof, wherein the pharmaceutical solution comprises an acceptable amount for ophthalmic topical administration of:
- (a) levcromakalim at a concentration between about 0.05 mM to about 5 mM;
- (b) an ethoxylated glycerol ester;
- (c) a polyethoxylated furanose fatty acid ester;
- (d) a polymeric lactam;
- (e) a nonionic tri-block copolymer of a central hydrophobic chain of polyoxypropylene flanked by two hydrophilic chains of polyoxyethylene;
- (f) a polyol;
- and
- (g) water and phosphate buffer as aqueous components;
- wherein the pH of the pharmaceutical solution is between 6 to 8.
A method of treating diabetic retinopathy comprising administering an effective amount of an aqueous clear ocular topical pharmaceutical solution to a human in need thereof, wherein the pharmaceutical solution comprises an acceptable amount for ophthalmic topical administration of:
- (a) levcromakalim at a concentration between about 0.05 mM to about 5 mM;
- (b) an ethoxylated glycerol ester;
- (c) a polyethoxylated furanose fatty acid ester;
- (d) a polymeric lactam;
- (e) a nonionic tri-block copolymer of a central hydrophobic chain of polyoxypropylene flanked by two hydrophilic chains of polyoxyethylene;
- (f) a polyol;
- and
- (g) water and phosphate buffer as aqueous components;
- wherein the pH of the pharmaceutical solution is between 6 to 8.
Dependencies are inferred from the claim text.