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AssigneeShinkei Therapeutics, Inc.
InventorsGurpartap Singh Sachdeva, Suresh Borsadia, Kalpana Patel, Krunal Raval
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A method and composition is described for treating impaired neurological function, CNS disease or condition, including altered state of consciousness disorders in a human subject, comprising parenterally administering a composition comprising aminoadamantane derivatives or salts thereof, alone or in combination with other neuroprotective and/or anti-inflammatory compounds, in a pharmacologically effective amount. In some embodiments, a method for treating traumatic brain injury caused by a stroke or an accident in a human subject is provided comprising intravenously administering a composition comprising amantadine hydrochloride in a pharmacologically effective amount to the subject in need thereof.
A method of treating traumatic brain injury (TBI) in a human subject comprising:
A method of treating mild or severe traumatic brain injury (TBI) in a human subject comprising intravenously administering a composition consisting of a daily dosage of about 200 mg to about 400 mg of amantadine hydrochloride in a vehicle, wherein the vehicle is selected from the group consisting of sterile water for injection, ethanol, a mixture of water for injection and ethanol, 5% dextrose solution, and 0.9% saline solution, wherein the composition is administered at a rate of about 15 mg/hr to about 135 mg/hr of amantadine hydrochloride, the composition has a volume of about 100 ml to about 1000 ml, and the composition is administered once or twice daily.
A method of treating mild or severe traumatic brain injury (TBI) in a human subject comprising intravenously administering a pharmaceutical composition consisting of a daily dosage of about 200 mg to about 400 mg of amantadine hydrochloride, wherein the method comprises:
Dependencies are inferred from the claim text.