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US 12,751,930 B2Granted
Cell-receptor targeted exosomes
AssigneeCity of Hope
InventorsKevin Morris, Tristan Scott
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Abstract
Provided herein are, inter alia, recombinant fusion proteins and exosomes comprising recombinant fusion proteins; wherein the recombinant fusion proteins comprises exosome membrane-associated proteins and exogenous target proteins; pharmaceutical compositions; and methods of using the recombinant fusion proteins, exosomes, and pharmaceutical compositions to treat diseases such as cancer, HIV, and COVID-19.
Claims18
An exosome comprising a recombinant fusion protein, wherein the recombinant fusion protein comprises an exosome membrane-associated protein and an exogenous target protein;
- wherein
- (i) the exosome membrane-associated protein is CD63, and
- (ii) the recombinant fusion protein comprises the exogenous target protein within extracellular loop 2.4 of CD63;
- wherein extracellular loop 2.4 of CD63 has an amino acid sequence that is at least 90% identical to SEQ ID NO:17.
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Dependencies are inferred from the claim text.