Engineered cells and uses thereof
AssigneeOhio State Innovation Foundation
InventorsYizhou Dong, Xucheng Hou, Xinfu Zhang
Life of this patent
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Abstract
The present disclosure relates to antigen presenting cells and uses thereof for treating sepsis. In some aspects, disclosed herein is an antigen presenting cell, comprising: a lipid-based nanoparticle, comprising: a recombinant polynucleotide, comprising: a first nucleic acid encoding an antimicrobial peptide; a second nucleic acid encoding cathepsin B; and a third nucleic acid encoding a linker; and a vitamin-lipid.
Claims18
An antigen presenting cell, comprising:
- a lipid-based nanoparticle, comprising:
- a recombinant polynucleotide, comprising:
- a first nucleic acid encoding an antimicrobial peptide;
- a second nucleic acid encoding cathepsin B;
- and
- a third nucleic acid encoding a linker;
- and
- a vitamin-lipid, wherein the vitamin-lipid comprises a vitamin moiety, and
- wherein the vitamin moiety comprises vitamin C.
An antigen presenting cell, comprising:
- a lipid-based nanoparticle, comprising:
- a recombinant polynucleotide, comprising:
- a first nucleic acid encoding an antimicrobial peptide;
- a second nucleic acid encoding cathepsin B;
- and
- a third nucleic acid encoding a linker;
- and a vitamin-lipid, wherein the vitamin-lipid is selected from the group consisting of:
- wherein R is
A method of treating sepsis, comprising administering to a subject one or more antigen presenting cells comprising:
- a nanoparticle, comprising:
- a recombinant polynucleotide, comprising:
- a first nucleic acid encoding an antimicrobial peptide,
- a second nucleic acid encoding cathepsin B, and
- a third nucleic acid encoding a linker;
- and
- a vitamin-lipid, wherein the vitamin-lipid comprises a vitamin moiety, and
- wherein the vitamin moiety comprises vitamin C.
Dependencies are inferred from the claim text.