Medication that protects the intestinal microbiota and their preparation methods and applications

Abstract

An orally administered antibiotic encapsulated in nanospheres, as well as its preparation method and application. The antibiotic encapsulated in the nanospheres includes an antibiotic and a degradable biocompatible polymer that encapsulates the antibiotic, wherein biocompatible polymer includes monosaccharide-modified poly (ethylene glycol)-poly(lactic-co-glycolic acid) (PEG-PLGA), which can significantly improves the damage caused by oral antibiotics to the intestinal microbiota, avoids destruction of the microbial community, thereby preventing chronic diseases associated with intestinal microbial imbalance, and a good biocompatibility and long-term safety.

Dependencies are inferred from the claim text.