System, method, and computer readable medium for a basal rate profile adaptation algorithm for closed-loop artificial pancreas systems

A computer-implemented method to control an insulin dosage by adapting a basal rate profile, the method comprising:

• receiving glucose level measurement data and the basal rate profile, wherein the basal rate profile includes a basal rate set point that corresponds to an insulin delivery reference basal rate at which an amount of glucose present in blood of a patient tends to stabilize, and wherein the basal rate profile is stored in a computer memory;
• updating the basal rate set point for a time period t based on:
• an assessment of at least one of a risk of hyperglycemia or a risk of hypoglycemia, the assessment performed on glucose level measurement data corresponding to a time period T, wherein T is a past time period, and t is a current or future time period corresponding to T;
• data corresponding to insulin infusions delivered to the patient during the time period T to mitigate glycemic risk;
• a minimum length of time constituting at least one of an addressable hyperglycemia risk zone or an addressable hypoglycemia risk zone;
• and
• a zone attribution parameter associated with the at least one of the addressable hyperglycemia risk zone or the addressable hypoglycemia risk zone, wherein the zone attribution parameter weights adjustments to the basal rate set point toward the at least one of the addressable hyperglycemia risk zone or the addressable hypoglycemia risk zone;
• and
• transmitting a control signal that will cause an insulin dispensing device to administer insulin in accordance with the updated basal rate set point.

A non-transitory computer readable recording medium encoded with a computer program comprising program instructions for causing a system to control an insulin dosage by adapting a basal rate profile, the computer program causing the system to:

• receive glucose level measurement data and the basal rate profile, wherein the basal rate profile includes a basal rate set point that corresponds to an insulin delivery reference basal rate at which an amount of glucose present in blood of a patient tends to stabilize, and wherein the basal rate profile is stored in a computer memory;
• update the basal rate set point for a time period t based on:
• an assessment of at least one of a risk of hyperglycemia or a risk of hypoglycemia, the assessment performed on glucose level measurement data corresponding to a time period T, wherein T is a past time period, and t is a current or future time period corresponding to T;
• data corresponding to insulin infusions delivered to the patient during the time period T to mitigate glycemic risk;
• a minimum length of time constituting at least one of an addressable hyperglycemia risk zone or an addressable hypoglycemia risk zone;
• and
• a zone attribution parameter associated with the at least one of the addressable hyperglycemia risk zone or the addressable hypoglycemia risk zone, wherein the zone attribution parameter weights adjustments to the basal rate set point toward the at least one of the addressable hyperglycemia risk zone or the addressable hypoglycemia risk zone;
• and
• transmit a control signal that will cause an insulin dispensing device to administer insulin in accordance with the updated basal rate set point.