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US 12,749,196 B2Granted
Left atrial appendage segmentation and quantification in 3D and 4D cardiac ultrasound
AssigneeSiemens Medical Solutions USA, Inc.
InventorsYue Zhang, Puneet Sharma
Life of this patent
Estimating the term…
Abstract
Systems and methods for real time three-dimensional left atrial appendage (LAA) quantification. Deep learning is used to perform LAA segmentation, tracking and live quantification on critical measurement in 4D ultrasound sequences. The collected information may be used for device selection and anomaly detection to assist early-phase disease finding.
Claims16
A method for real time three-dimensional left atrial appendage quantification, the method comprising:
- acquiring a real time three-dimensional ultrasound sequence of a patient;
- selecting a seed location of the left atrial appendage in a frame of the real time three-dimensional ultrasound sequence;
- cropping the frame to a region of interest based on the seed location;
- generating an initial three-dimensional left atrial appendage segmentation from the region of interest;
- extracting one or more landmarks from the three-dimensional left atrial appendage segmentation;
- slicing the initial three-dimensional left atrial appendage segmentation into a plurality of two-dimensional slices, wherein the plurality of two-dimensional slices each include a portion of a contour of the left atrial appendage;
- tracking the contour of the left atrial appendage in the plurality of two-dimensional slices for a plurality of subsequent frames of the real time three-dimensional ultrasound sequence and tracking the one or more landmarks in the real time three-dimensional ultrasound sequence;
- generating a real time three-dimensional left atrial appendage segmentation for each of the plurality of subsequent frames by aggregating the tracked contours from the two-dimensional slices for each respective subsequent frame;
- and
- quantifying at least one morphological metric from the tracked contour and/or the tracked one or more landmarks, wherein the at least one morphological metric comprises a diameter of the left atrial appendage over time, wherein the quantified diameter is used to determine a property of a device in a left atrial appendage closure procedure.
7 more elements
A system for real time three-dimensional left atrial appendage segmentation, the system comprising:
- an ultrasound imaging system configured to acquire a 4D ultrasound sequence of patient;
- and
- a processor configured to:
- select a seed location of the left atrial appendage in a frame of the 4D ultrasound sequence,
- crop the frame to a region of interest based on the seed location,
- generate an initial three-dimensional left atrial appendage segmentation from the region of interest,
- extract one or more landmarks from the initial three-dimensional left atrial appendage segmentation,
- slice the initial three-dimensional left atrial appendage segmentation into a plurality of two-dimensional slices, wherein the plurality of two-dimensional slices each include a portion of a contour of the left atrial appendage,
- track the contour in the plurality of two-dimensional slices over time and the one or more landmarks in the 4D ultrasound sequence,
- generate a real time three-dimensional left atrial appendage segmentation for each of the plurality of subsequent frames by aggregating the tracked contours from the two-dimensional slices for each respective subsequent frame,
- quantify at least one morphological metric from the tracked contour and/or the tracked one or more landmarks, wherein the at least one morphological metric comprises a diameter of the left atrial appendage over time, and
- cause a display to present the quantified diameter for use in determining a property of a device in a left atrial appendage closure procedure.
9 more elements
A system comprising:
- an ultrasound imaging system configured to acquire a 4D ultrasound sequence of patient;
- a display configured to display the 4D ultrasound sequence;
- an input device configured to identify a seed location for a left atrial appendage in a frame of the 4D ultrasound sequence;
- and
- a processor configured to:
- crop the frame to a region of interest based on the seed location,
- generate an initial three-dimensional left atrial appendage segmentation from the region of interest,
- slice the initial three-dimensional left atrial appendage segmentation into a plurality of two-dimensional slices, wherein the plurality of two-dimensional slices each include a portion of a contour of the left atrial appendage,
- track the contour in the plurality of two-dimensional slices in real time,
- generate a real time three-dimensional left atrial appendage segmentation for each of the plurality of subsequent frames by aggregating the tracked contours from the two-dimensional slices for each respective subsequent frame,
- identify one or more landmarks in the three-dimensional left atrial appendage segmentation and track the one or more landmarks over time in the 4D ultrasound sequence, and
- quantify at least one metric from the real time three-dimensional left atrial appendage segmentation and/or the tracked one or more landmarks.
9 more elements
Dependencies are inferred from the claim text.