Progressive exploitation of multi-energy and photon counting modalities
AssigneeElucid Bioimaging Inc.
InventorsAndrew J. Buckler, Changguo Ji, Murali Ayyapillai
Life of this patent
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Abstract
Systems and methods for improving soft tissue contrast, characterizing tissue, classifying phenotype, stratifying risk, and performing multi-scale modeling aided by multiple energy or contrast excitation and evaluation are provided. The systems and methods can include single and multi-phase acquisitions and broad and local spectrum imaging to assess atherosclerotic plaque tissues in the vessel wall and perivascular space.
Claims20
A computerized method for determining and displaying mixed tissue types of microcalcification screen and dense calcification regions using radiological images, the method comprising:
- i) performing, via a processor, multiple energy photon-counting K-edge subtraction on the radiological images;
- ii) performing, via the processor, spectral image denoising with regularization models on the radiological images;
- iii) subtracting, via the processor, i) from ii) to improve calcium detected in the radiological images by improving signal to noise ratio;
- iv) performing, via the processor, segmentation on the improved calcium detected in the radiological images to determine the dense calcification regions and the microcalcification screen;
- and
- v) transmitting, via the processor, the dense calcification regions, the microcalcification screen or both to a display.
A system for determining and displaying mixed tissue types of microcalcification screen and dense calcification regions using radiological images, the system comprising:
- a processor configured to:
- i) perform multiple energy photon-counting K-edge subtraction on the radiological images;
- ii) perform spectral image denoising with regularization models on the radiological images;
- iii) subtract i) from ii) to improve calcium detected in the radiological images by improving signal to noise ratio;
- iv) perform segmentation on the improved calcium detected in the radiological images to determine the dense calcification regions and the microcalcification screen;
- and
- v) transmit the dense calcification regions, the microcalcification screen or both to a display.
A non-transitory computer program product comprising instructions which, when the program is executed cause a processor to:
- i) perform multiple energy photon-counting K-edge subtraction on the radiological images;
- ii) perform spectral image denoising with regularization models on the radiological images;
- iii) subtract i) from ii) to improve calcium detected in the radiological images by improving signal to noise ratio;
- iv) perform segmentation on the improved calcium detected in the radiological images to determine a microcalcification screen and dense calcification regions;
- and
- v) transmit the dense calcification regions, the microcalcification screen or both to a display.
Dependencies are inferred from the claim text.