Fluidic network for positive displacement aseptic sampling

A method for aseptic process sampling, the method comprising:

• providing a fluidic network for aseptic process sampling including:
• a sampling valve configurable in at least a first sampling valve state and a second sampling valve state and including a process inlet port to receive a process sample, a process outlet port to provide the process sample, and a plurality of valve channels,
• a sample treatment module comprising a filtration element and a sample preparation element in fluidic communication with each other;
• a positive displacement pump;
• a selector valve disposed in a fluidic path between and in fluidic communication with the sampling valve and the sample treatment module, the selector valve being in further fluidic communication with the positive displacement pump, the selector valve being configurable in a first selector valve state in which the sampling valve is fluidically coupled to the positive displacement pump, a second selector valve state in which the positive displacement pump is fluidically coupled to the sample treatment module and a third selector valve state in which the sampling valve is fluidically coupled to the sample treatment module;
• and
• a valve control module in communication with the sampling valve and the selector valve and configured to control the valve states thereof,
• wherein, a process sample path is defined between the process inlet port and the process outlet port and includes the sample treatment module and at least one valve channel of the sampling valve,
• wherein, when the sampling valve is in the first sampling valve state and the selector valve is in the first selector valve state, a section of the process sample path receives the process sample by a draw operation of the positive displacement pump, and
• wherein, when the sampling valve is in the first sampling valve state and the selector valve is in the second selector valve state, at least a portion of the process sample received in the section of the process sample path is pushed through the sample treatment module by operation of the positive displacement pump;
• drawing the process sample from a process source into the process sample path;
• pushing at least a portion of the process sample drawn into the process sample path in a forward direction through the sample treatment module to an injection valve;
• and
• pushing the portion of the process sample back toward the process source.