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US 12,748,114 B2Granted
Diagnosis, prognosis and treatment of malignant neoplasms
AssigneeRhode Island Hospital
InventorsJack R. Wands, Rolf I. Carlson, Xiaoqun Dong
Life of this patent
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Abstract
This disclosure relates to antibodies and derivatives that bind the full-length isoform of aspartate beta-hydroxylase (ASPH) and uses thereof. The antibodies and derivatives are useful in compositions and methods for detecting and/or treating a malignant neoplasm in a subject and for predicting subsequent complications of untreated progression of the malignant neoplasm in the subject.
Claims8
An antibody that binds to the full-length isoform of aspartate beta-hydroxylase (ASPH) comprising a light chain and a heavy chain,
- wherein the light chain comprises a light chain variable region (LCVR) and the heavy chain comprises a heavy chain variable region (HCVR),
- wherein the LCVR comprises complementarity determining regions LCDR1, LCDR2, and LCDR3, and the HCVR comprises complementarity determining regions HCDR1, HCDR2, and HCDR3, and
- wherein LCDR1 consists of amino acid sequence SEQ ID NO:
- 5, LCDR2 consists of amino acid sequence SEQ ID NO:
- 6, LCDR3 consists of amino acid sequence SEQ ID NO:
- 7, HCDR1 consists of amino acid sequence SEQ ID NO:
- 2, HCDR2 consists of amino acid sequence SEQ ID NO:
- 3, and HCDR3 consists of amino acid sequence SEQ ID NO:
- 4.
6 more elements
Dependencies are inferred from the claim text.