US 12,748,088 B2Granted

Method and system for detection and analysis of chemical compounds in a sample subjected to a chromatographic separation on a layered separating medium

AssigneeTechnion Research & Development Foundation Limited

InventorsHossam Haick, Arnab Maity

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Abstract

A method and system in the present invention allow to detect and analyse chemical compounds in a sample subjected to chromatographic separation on a layered medium. The system comprises a detector comprising an array of sensors printed on each layer of the separating medium, and providing information on the presence and properties of the tested compounds in the sample. The machine-learning methods used in the method of the invention are shown to be the methods of choice when analysing the spectrometry data, for example μGC data, in a variety of scenarios and in a variety of applications, including real-time molecular analysis. These machine-learning methods can effectively learn the spectroscopic and chromatographic models taking into account various kinetic and thermodynamic parameters and by that constitute an advantageous alternative to traditional spectroscopic and chromatographic analytical methods.

Claims20

Dependent claims

A method for detection and analysis of chemical compounds in a sample, wherein said method comprises:

(1) subjecting the sample to chromatographic separation on a layered separating medium;
(2) detection of chemical compounds in the sample separated on the layers of said separating medium with a detector, said detector comprises an array of sensors printed on each layer of said separating medium and generates data, said data comprises a string or an array of measurement results from each said sensor on each said layer of the separating medium, said string or array of the measurement results is an input for an external memory;
and
(3) processing said data in the external memory by applying a machine-learning method on said measurement results to output a single bit whose value is ‘0’ or ‘1’, or an array of bits, or an array of integers, or an array of complex numbers, wherein said single bit, or said array of bits, or said array of integers, or said array of complex numbers corresponds to an estimated frequency, voltage, sensor conductance, electrical resistance, time of chromatographic elution, or mass-to-charge ratio, and to maximum availability or amplitude of the input, thereby providing information on the presence and properties of said compounds in the sample.

1 more element

A system for detection and analysis of chemical compounds in a sample subjected to a chromatographic separation on a layered separating medium, said system comprising:

(a) said layered separating medium for chromatographic separation of the compounds contained in the sample and for providing physical support for an embedded electronics and detector;
(b) said detector comprising an array of sensors printed on each layer of said separating medium, and providing information on the presence and properties of said compounds in the sample;
(c) said embedded electronics printed on each layer of said separating medium and comprising at least one of the following:
(1) a voltage source connected to said detector and said chemical sensors via a microelectronic circuit for supplying electric current to said detector and sensors;
(2) an integrated or CMOS current amplifier connected to said voltage source for amplification of an electric current obtained from said detector and said sensors;
(3) an analogue-to-digital converter (ADC) with in-built digital input/output card connected to said current amplifier for outputting the converted signal to the external memory;
and
(4) a wired or wireless connection module for connecting said system to said external memory;
and
(d) an external memory.

7 more elements

Dependencies are inferred from the claim text.

Facts

Application: 18/578,754Filed 3 May 2022 · us provisional application
Priority: 1 Aug 2021
Published: US 2024/0337630 A110 Oct 2024
Granted: 29 Sep 2026
Term ends: Not estimatedThe source records don’t support an estimate.

Classification12 codes

G01N 30/95
Plate chromatography, e.g. thin layer or paper chromatography: detectors specially adapted therefor; Signal analysis
C09D 11/30
Inks: inkjet printing inks
C09D 11/52
Inks: electrically conductive inks
G01N 30/92
Plate chromatography, e.g. thin layer or paper chromatography: construction of the plate