Circuit design to apply different voltages in a nanopore array
AssigneeIllumina, Inc.
InventorsMohsen Rezaei, Xu Liu, Arvin Emadi
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Abstract
In one aspect, the disclosed technology relates to systems and methods for sequencing polynucleotides. In one embodiment, the disclosed system for sequencing polynucleotides includes: a sequencing cell comprising a nanopore for sensing a polynucleotide; an electronic circuit configured to measure an electrical response in the sequencing cell, the electronic circuit comprising an operational amplifier; and a memory unit configured to store a state of the sequencing cell.
Claims18
A device for sequencing polynucleotides, comprising:
- at least one voltage source;
- and
- at least two sequencing units, each comprising:
- a sequencing cell comprising a nanopore for sensing a polynucleotide;
- an electronic circuit configured to measure an electrical response in the sequencing cell, the electronic circuit comprising an operational amplifier, a positive input terminal of the operational amplifier operably connected to said at least one voltage source via at least one switch;
- and
- a memory unit configured to store a state of the sequencing cell, at least some output terminals of the memory unit operably connected to the at least one switch.
A device for sequencing polynucleotides, comprising at least two sequencing units, each comprising:
- a sequencing cell comprising a nanopore for sensing a polynucleotide;
- an electronic circuit configured to measure an electrical response in the sequencing cell, the electronic circuit comprising an operational amplifier, a negative input terminal of the operational amplifier operably connected to the sequencing cell via a gate;
- and
- a memory unit configured to store a state of the sequencing cell, at least some output terminals of the memory unit operably connected to the gate.
Dependencies are inferred from the claim text.