Compositions and methods for reprogramming age-restricted non-neuronal cells
AssigneeThe Regents of the University of California
InventorsXiang-Dong Fu, Hao Qian
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Abstract
Provided herein are compositions and methods for reprogramming a non-neuronal cell to a neuron. Aspects of the present disclosure relate to compositions and methods for transdifferentiating an age-restricted non-neuronal cell into a neuron. Also provided herein is a method of treating neurodegenerative disease by reprogramming region or anatomy specific non-neuronal cells into specific types of functionalized neurons.
Claims3
A vector comprising at least one coding sequence for shPTB comprising SEQ ID NO:2 or 3, a coding sequence for an miR-9 comprising SEQ ID NO:4 or 5, and a coding sequence for an miR-124 comprising SEQ ID NO:6 or 7.
Dependencies are inferred from the claim text.