Back to results
US 12,747,431 B2Granted
Modulation of expression of genes related to T cell exhaustion
AssigneeThe Trustees of the University of Pennsylvania
InventorsE. John Wherry, Omar Khan, Josephine Giles
Life of this patent
Estimating the term…
Abstract
The present invention provides methods of preventing, reducing or reversing T cell exhaustion in a patient having a disease. The present invention also provides methods for treating a disease in a patient having the disease. The present invention also provides an engineered T cell, and uses thereof.
Claims29
A cell therapy composition comprising engineered T cells made by the process comprising the steps of:
- (a) altering a non-coding DNA sequence comprising a regulatory domain present in an open chromatin region (OCR) associated with expression of one or more exhaustion-specific genes in a sample of T cells obtained from a subject;
- and
- (b) engineering the T cells to target an antigen;
- wherein the altered non-coding DNA sequence reduces or reverses exhaustion of the T cells;
- wherein the one or more exhaustion-specific genes is Zinc-finger CCCH-type containing 12C protein (ZC3H12C);
- and
- wherein the altering of the non-coding DNA sequence decreases expression of ZC3H12C.
4 more elements
Dependencies are inferred from the claim text.