Compositions and systems for ex vivo cell modulation and methods of use thereof

Abstract

Bioreactor devices for modulating cells, systems including the devices, and methods of using the devices and systems to modulate cells are provided. The bioreactor devices typically include (i) a base support; (ii) a scaffold having bound to or present on the surface thereof, one or more cell receptor ligands; and (iii) a biodegradable polymer, co-polymer, or blend of polymers including an active agent associated with, encapsulated within, surrounded by, and/or dispersed therein. The systems include a bioreactor device, and one or more additional components, such as a housing for the device, one or more flow lines, one or more ports, one or more valves or clamps, etc. Methods of using the devices and systems for modulating cells ex vivo and treating subjects with cell adaptive therapy are also provided.

Dependencies are inferred from the claim text.