Back to results
US 12,747,299 B2Granted
CD40 binding molecules and uses thereof
AssigneesMemorial Sloan Kettering Cancer Center, Tri-Institutional Therapeutics Discovery Institute, Inc.
InventorsDanny Nejad Khalil, Taha Merghoub, Jedd D. Wolchok, Isabell Schulze, Ivo C. Lorenz
Life of this patent
Estimating the term…
Abstract
The present invention provides various CD40 binding molecules (including, but not limited to, antibodies), compositions comprising such CD40 binding molecules, and methods of using such CD40 binding molecules and compositions, for example for CD40-mediated activation of cells, such as antigen presenting cells.
Claims19
An isolated CD40 binding molecule comprising:
- (i) CDR H1 and CDR H2 regions of SEQ ID NO. 1,
- (ii) CDR H3 region of SEQ ID NO. 1, 3, 5, 7, or 17, and
- (iii) CDR L1, CDR L2, and CDR L3 regions of SEQ ID NO. 2,
- wherein the molecule binds to, and is an agonist of, human CD40.
1 more element
An isolated CD40 binding molecule comprising:
- (i) CDR H1 and CDR H2 regions of SEQ ID NO. 1,
- (ii) CDR H3 region comprising, and
- (iii) CDR L1, CDR L2, and CDR L3 regions of SEQ ID NO. 2,
- wherein the molecule binds to, and is an agonist of, human CD40.
1 more element
Dependencies are inferred from the claim text.