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US 12,747,298 B2Granted
Multi-specific antibodies binding to BCMA
AssigneeTeneoBio, Inc.
InventorsNathan Trinklein, Katherine Harris, Harbani Malik, Ute Schellenberger, Omid Vafa, Shelley Force Aldred
Life of this patent
Estimating the term…
Abstract
Multi-specific, human heavy chain antibodies (e.g., UniAbsm) binding to BCMA are disclosed, along with methods of making such antibodies, compositions, including pharmaceutical compositions, comprising such antibodies, and their use to treat disorders that are characterized by the expression of BCMA.
Claims26
A multi-specific antibody comprising:
- (a) a first binding unit that binds to La protein, comprising:
- (i) a heavy chain variable region comprising:
- a CDR1 sequence of SEQ ID NOs:
- 4 or 7, a CDR2 sequence of SEQ ID NO:
- 5, and a CDR3 sequence of SEQ ID NO:
- 6 or 8, in a human VH framework;
- and
- (ii) a light chain variable region comprising:
- a CDR1 sequence of SEQ ID NO:
- 9, a CDR2 sequence of SEQ ID NO:
- 10, and a CDR3 sequence of SEQ ID NO:
- 11, in a human VL framework;
- and
- (b) a second binding unit that binds to BCMA, comprising:
- (i) an antigen-binding domain of an anti-BCMA heavy chain-only antibody, comprising a CDR1 sequence of SEQ ID NO:
- 1, a CDR2 sequence of SEQ ID NO:
- 2, and a CDR3 sequence of SEQ ID NO:
- 3, in a human VH framework, wherein the antigen-binding domain of the anti-BCMA heavy chain-only antibody is in a monovalent or bivalent configuration.
15 more elements
A bispecific three-chain antibody-like molecule that binds to BCMA and La protein, comprising:
- (i)
- (a) a first heavy chain polypeptide subunit comprising the sequence of SEQ ID NO:
- 18;
- (b) a second heavy chain polypeptide subunit comprising the sequence of SEQ ID NO:
- 24;
- and
- (c) a first light chain polypeptide subunit comprising the sequence of SEQ ID NO:
- 20;
- or
- (ii)
- (a) a first heavy chain polypeptide subunit comprising the sequence of SEQ ID NO:
- 18;
- (b) a second heavy chain polypeptide subunit comprising the sequence of SEQ ID NO:
- 26;
- and
- (c) a first light chain polypeptide subunit comprising the sequence of SEQ ID NO:
- 20;
- or
- (iii)
- (a) a first heavy chain polypeptide subunit comprising the sequence of SEQ ID NO:
- 21;
- (b) a second heavy chain polypeptide subunit comprising the sequence of SEO ID NO:
- 24;
- and
- (c) a first light chain polypeptide subunit comprising the sequence of SEQ ID NO:
- 23;
- or
- (iv)
- (a) a first heavy chain polypeptide subunit comprising the sequence of SEO ID NO:
- 21;
- (b) a second heavy chain polypeptide subunit comprising the sequence of SEQ ID NO:
- 26;
- and
- (c) a first light chain polypeptide subunit comprising the sequence of SEQ ID NO:
- 23;
- or
- (v)
- (a) a first heavy chain polypeptide subunit comprising the sequence of SEQ ID NO:
- 19;
- (b) a second heavy chain polypeptide subunit comprising the sequence of SEQ ID NO:
- 25;
- and
- (c) a first light chain polypeptide subunit comprising the sequence of SEO ID NO:
- 20;
- or
- (vi)
- (a) a first heavy chain polypeptide subunit comprising the sequence of SEQ ID NO:
- 19;
- (b) a second heavy chain polypeptide subunit comprising the sequence of SEO ID NO:
- 27;
- and
- (c) a first light chain polypeptide subunit comprising the sequence of SEQ ID NO:
- 20;
- or
- (vii)
- (a) a first heavy chain polypeptide subunit comprising the sequence of SEO ID NO:
- 22;
- (b) a second heavy chain polypeptide subunit comprising the sequence of SEO ID NO:
- 25;
- and
- (c) a first light chain polypeptide subunit comprising the sequence of SEQ ID NO:
- 23;
- or
- (viii)
- (a) a first heavy chain polypeptide subunit comprising the sequence of SEQ ID NO:
- 22;
- (b) a second heavy chain polypeptide subunit comprising the sequence of SEQ ID NO:
- 27;
- and
- (c) a first light chain polypeptide subunit comprising the sequence of SEQ ID NO:
- 23.
68 more elements
Dependencies are inferred from the claim text.