Bispecific antibody simultaneously binding to interleukin-4 receptor alpha subunit and interleukin-5 receptor alpha subunit, encoding nucleic acids thereof and methods of use thereof for treatment

A bispecific antibody or antigen-binding fragment thereof binding to both IL-4Rα and IL-5Rα comprising:

• an antibody or an antigen-binding fragment thereof binding to interleukin (IL)-4 receptor α (IL-4Rα, CD124) comprising:
• a heavy-chain CDR1 of SEQ ID NO:
• 1, a heavy-chain CDR2 of SEQ ID NO:
• 5, a heavy-chain CDR3 of SEQ ID NO:
• 8, a light-chain CDR1 of SEQ ID NO:
• 13, a light-chain CDR2 of SEQ ID NO:
• 14, and a light-chain CDR3 of SEQ ID NO:
• 16;
• a heavy-chain CDR1 of SEQ ID NO:
• 1, a heavy-chain CDR2 of SEQ ID NO:
• 6, a heavy-chain CDR3 of SEQ ID NO:
• 8, a light-chain CDR1 of SEQ ID NO:
• 13, a light-chain CDR2 of SEQ ID NO:
• 14, and a light-chain CDR3 of SEQ ID NO:
• 17;
• a heavy-chain CDR1 of SEQ ID NO:
• 1, a heavy-chain CDR2 of SEQ ID NO:
• 5, a heavy-chain CDR3 of SEQ ID NO:
• 8, a light-chain CDR1 of SEQ ID NO:
• 13, a light-chain CDR2 of SEQ ID NO:
• 14, and a light-chain CDR3 of SEQ ID NO:
• 18;
• a heavy-chain CDR1 of SEQ ID NO:
• 1, a heavy-chain CDR2 of SEQ ID NO:
• 3, a heavy-chain CDR3 of SEQ ID NO:
• 8, a light-chain CDR1 of SEQ ID NO:
• 13, a light-chain CDR2 of SEQ ID NO:
• 14, and a light-chain CDR3 of SEQ ID NO:
• 19;
• or
• a heavy-chain CDR1 of SEQ ID NO:
• 1, a heavy-chain CDR2 of SEQ ID NO:
• 5, a heavy-chain CDR3 of SEQ ID NO:
• 8, a light-chain CDR1 of SEQ ID NO:
• 13, a light-chain CDR2 of SEQ ID NO:
• 14, and a light-chain CDR3 of SEQ ID NO:
• 20;
• and
• an antibody or an antigen-binding fragment thereof binding to interleukin (IL)-5 receptor α(IL-5Rα, CD125) comprising:
• a heavy-chain CDR1 of SEQ ID NO:
• 27, a heavy-chain CDR2 selected of SEQ ID NO:
• 28, a heavy-chain CDR3 of SEQ ID NO:
• 30, a light-chain CDR1 of SEQ ID NO:
• 43, a light-chain CDR2 of SEQ ID NO:
• 44, and a light-chain CDR3 of SEQ ID NO:
• 45;
• a heavy-chain CDR1 of SEQ ID NO:
• 27, a heavy-chain CDR2 of SEQ ID NO:
• 28, a heavy-chain CDR3 of SEQ ID NO:
• 31, a light-chain CDR1 of SEQ ID NO:
• 43, a light-chain CDR2 of SEQ ID NO:
• 44, and a light-chain CDR3 of SEQ ID NO:
• 45;
• a heavy-chain CDR1 of SEQ ID NO:
• 27, a heavy-chain CDR2 of SEQ ID NO:
• 28, a heavy-chain CDR3 of SEQ ID NO:
• 32, a light-chain CDR1 of SEQ ID NO:
• 43, a light-chain CDR2 of SEQ ID NO:
• 44, and a light-chain CDR3 of SEQ ID NO:
• 45;
• a heavy-chain CDR1 of SEQ ID NO:
• 27, a heavy-chain CDR2 of SEQ ID NO:
• 28, a heavy-chain CDR3 of SEQ ID NO:
• 33, a light-chain CDR1 of SEQ ID NO:
• 43, a light-chain CDR2 of SEQ ID NO:
• 44, and a light-chain CDR3 of SEQ ID NO:
• 45;
• a heavy-chain CDR1 of SEQ ID NO:
• 27, a heavy-chain CDR2 of SEQ ID NO:
• 28, a heavy-chain CDR3 of SEQ ID NO:
• 34, a light-chain CDR1 of SEQ ID NO:
• 43, a light-chain CDR2 of SEQ ID NO:
• 44, and a light-chain CDR3 of SEQ ID NO:
• 45;
• or
• a heavy-chain CDR1 of SEQ ID NO:
• 27, a heavy-chain CDR2 of SEQ ID NO:
• 28, a heavy-chain CDR3 of SEQ ID NO:
• 30, a light-chain CDR1 of SEQ ID NO:
• 43, a light-chain CDR2 of SEQ ID NO:
• 44, and a light-chain CDR3 of SEQ ID NO:
• 35.